1, 3-Dipolar Cycloaddition of Nitrones to Enamines

A homo [3+2] dipolar cycloaddition: the reaction of nitrones with cyclopropanes.

Cycloadditions are among the most trusted of chemical transformations available to the synthetic chemist. The predictability of the transition state based on steric and electronic considerations allows for the strategic construction of complex molecular assemblies. While the Diels–Alder reaction has received the most attention, 1,3-dipolar cycloadditions have also maintained a place of prominen...

1,3-Dipolar Cycloaddition Reaction of Nitrile Oxides to Isatin Imines

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1,3-Dipolar [3 + 2] cycloaddition reactions of N,C,C-trisubstituted nitrones with ring-acceptor methylenecyclopropanes: a computational study

BACKGROUND 1,3-Dipolar [3 + 2]-cycloaddition of nitrones to the carbon-carbon double bonds of methylenecyclopropanes yields a mixture of regioisomeric 4- and 5-isoxazolidines. The mechanisms of the reactions of N,C,C-trisubstituted nitrones with ring acceptor substituted dimethyl methylenecyclopropanes-1,2-dicarboxylate and aryl methylidene cyclopropanes-1,1-dicarboxylate have been investigated...

STUDY OF CYCLOREVERSION OF NTTRONE-CY CLODIMERS

A series of 1,3-dipolar cycloaddition reactions are carried out using cyclodimers of simple nitrones and various dipolarophiles; substituted isoxazolidines are isolated and identified. It is proved that such cyclodimers, in solution, are in equilibrium with their corresponding nitrones and enamines. It is also concluded that aldocyclodimers are more potent than keto-cyclodimers in establish...

Stereoselective intermolecular formal [3+3] cycloaddition reaction of cyclic enamines and enones.